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KMID : 1144720190230010017
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Investigative Magnetic Resonance Imaging
2019 Volume.23 No. 1 p.17 ~ p.25
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Diagnostic Significance of pH-Responsive Gd3+-Based T1 MR Contrast Agents
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Bhuniya Sankarprasad
Hong Kwan-Soo
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Abstract
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We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
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KEYWORD
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MR contrast agent, pH-mapping, T1-W MRI
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